Posts Tagged ‘MARPLE’

MARPLE team awarded for international impact

Research team behind a revolutionary field test for wheat disease wins prestigious BBSRC prize

International Impact winners Diane Saunders and Dave Hodson with Malcolm Skingle, director of Academic Liaison, GlaxoSmithKline and Melanie Welham, executive chair of BBSRC. Photo ©BBSRC

The research team behind the MARPLE (Mobile And Real-time PLant disEase) diagnostic kit won the international impact category of the annual Innovator of the Year Awards sponsored by the UK Biotechnology and Biological Sciences Research Council (BBSRC).

The team — Diane Saunders of the John Innes Centre (JIC), Dave Hodson of the International Maize and Wheat Improvement Center (CIMMYT) and Tadessa Daba of the Ethiopian Institute of Agricultural Research (EIAR) — was presented with the award at a high-profile event at the London Science Museum on 15 May 2019 before an audience of leading figures from the worlds of investment, industry, government, charity and academia, including Chris Skidmore MP, Minister of State for Universities, Science, Research and Innovation.

The BBSRC Innovator of the Year awards, now in their 11th year, recognize and support individuals or teams who have taken discoveries in bioscience and translated them to deliver impact. Reflecting the breadth of research that BBSRC supports, they are awarded in four categories of impact: commercial, societal, international and early career.

Diane Saunders of John Innes Centre and Dave Hodson of CIMMYT pose with the MARPLE diagnostics kit. Credit: JIC

As finalists in the international impact category, Saunders, Hodson and Daba were among a select group of 12 finalists competing for the prestigious Innovator of the Year 2019 award. In addition to international recognition, they received a £10,000 award.

“I am delighted that this work has been recognized,” said Hodson. “Wheat rusts are a global threat to agriculture, and to the livelihoods of farmers in developing countries such as Ethiopia. MARPLE diagnostics puts state of the art, rapid diagnostic results in the hands of those best placed to respond: researchers on the ground, local government and farmers.”

MARPLE diagnostics is the first operational system in the world using nanopore sequence technology for rapid diagnostics and surveillance of complex fungal pathogens in the field.

In its initial work in Ethiopia, the suitcase-sized field test kit has positioned the country, among the region’s top wheat producers, as a world leader in pathogen diagnostics and forecasting. Generating results within 48 hours of field sampling, the kit represents a revolution in plant disease diagnostics with far-reaching implications for how plant health threats are identified and tracked into the future.

The MARPLE mobile lab in Ethiopia. Credit: JIC

MARPLE is designed to run at a field site without constant electricity and with the varying temperatures of the field.

“This means we can truly take the lab to the field,” explained Saunders. “Perhaps more importantly though, it means that smaller, less resourced labs can drive their own research without having to rely on a handful of large, well-resourced labs and sophisticated expertise in different countries.”

In a recent interview with JIC, EIAR Director Tadessa Daba said, “We want to see this project being used on the ground, to show farmers and the nation this technology works.”



Development of the MARPLE diagnostic kit was funded by the Biotechnology and Biological Sciences Research Council (BBSRC) and the CGIAR Platform for Big Data in Agriculture Inspire Challenge. Continued support is also provided by the BBSRC Excellence with Impact Award to the John Innes Centre and the Delivering Genetic Gain in Wheat project led by Cornell University International Programs that is funded by the UK Department for International Development (DFID) and the Bill & Melinda Gates Foundation.

More information on the JIC-CIMMYT-EIAR team’s BBSRC recognition can be found on the JIC website, the BBSRC website and the website of the CGIAR Research Program on Wheat.

Q&A with Dave Hodson on MARPLE and Big Data

CIMMYT’s Dave Hodson taking wheat rust samples with Ethiopian farmers. Photo credit: John Innes Centre

The MARPLE (Mobile And Real-time PLant disease) project – a project to test and pilot a revolutionary mobile lab in Ethiopia, led by the John Innes Centre, the International Maize and Wheat Improvement Center (CIMMYT) and the Ethiopian Institute of Agricultural Research (EIAR)—won the CGIAR Platform for Big Data in Agriculture Inspire Challenge Scale Up award in 2018.

The Inspire Challenge encourages CGIAR partners, universities and others to use big data approaches through innovative pilot projects to advance agricultural research and development. To be named a winner, projects must have real potential for developmental impact, have mobilized underused or misused data, and demonstrate meaningful partnerships with CGIAR and other sector members. Ultimately, the Inspire Challenge looks for novel approaches to inform policies and applications in agriculture and food security.

We sat down with CIMMYT Principal Scientist and rust pathologist Dave Hodson to ask him about the project and its relationship with Big Data for Agriculture.

What is the significance of Big Data to your work?
Advances in sequencing technology, and the use of innovative big data approaches on sequence data from thousands of yellow rust isolates, opened the door for Diane Saunders and colleagues at the John Innes Centre in the UK to develop revolutionary, near-real time, mobile pathogen diagnostic techniques using portable palm-sized gene sequencers. The final result being the first operational system in the world using nanopore sequence technology for rapid diagnostics and surveillance of complex fungal pathogens in situ.

How do you see the role of the CGIAR Platform for Big Data in Agriculture in your work?
Support from the CGIAR Big Data Platform was critical to establish the partnership between John Innes, the Ethiopian Institute of Agricultural Research (EIAR) and CIMMYT and enable piloting and testing of the new MARPLE diagnostic platform in Ethiopia. The choice of Ethiopia to be the first country for initial testing was based on several key factors. Firstly, a strong national partner in EIAR; secondly, the critical importance of wheat and wheat rust diseases in the country. Ethiopia is the largest wheat producer in sub-Saharan Africa, but it is also considered the gateway for new wheat rust strains entering into Africa from Asia. All these factors made Ethiopia the highest priority country to take the lead in testing this revolutionary new and rapid pathogen diagnostics platform.

How did it impact this MARPLE project?
The pilot and subsequent scale-up project from the CGIAR Big Data Platform has enabled in-country capacity to be developed, and cutting edge technology for rapid pathogen diagnostics to be deployed in the front-line in the battle against devastating wheat rust diseases. The scientific innovation in developing the MARPLE platform, coupled to the suitability of the technology for developing country partners has now attracted support and interest from other donors. Matching funds were recently obtained for the scale -up phase of MARPLE from the Delivering Genetic Gain in Wheat project (implemented by Cornell University and funded by the Bill and Melinda Gates Foundation and the UK Department for International Development). This scale-up phase of the project will see a set of distributed MARPLE hubs established and embedded within the Ethiopian wheat research system – resulting in a sentinel system for the rapid detection of new yellow rust races that is unparalleled anywhere in the world. The scientific breakthrough in developing rapid diagnostics for complex fungal pathogens using nanopore sequencing will permit the development of similar systems for other important fungal diseases in the future.

The MARPLE project was selected as a 2017 winner, with the team receiving 100,000 USD to put their ideas into practice. The team came runners up for the Scale Up award the following year, receiving an additional USD 125,000 for their outstanding ability to demonstrate the project’s proven viability and potential for impact.